From Psychoneuroimmunology to Immunometabolism: a New Reading for Oral Emerging Pathologies

Gingivitis and periodontitis are the two most common forms of oral emerging pathologies and recently the attention of researchers has focused on the relationship between abovementioned local pathologies and systemic chronic diseases. Especially several case-control and cohort studies have reported the contribution of obesity and type 2 diabetes due to their alarming spread in our western societies [1]. This evidence suggest that destructive periodontal disease is linked to obesity and metabolic syndrome, as an example of interorgan crosstalk under inflammatory conditions [2,3].